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Pigment and skin of color research: what the studies show

These papers measure dark spots and light spots after resurfacing and how to treat darker skin types safely.

Pigment and skin of color in plain words

Lasers and peels that smooth wrinkles injure the skin on purpose, and in medium and darker skin that injury often leaves temporary dark patches. Choosing a gentler device, the right settings and skin care before and after keeps the risk low.

What the research shows

Temporary darkening is the most common problem after resurfacing in darker skin. After full laser resurfacing in olive and light brown skin, about two in three patients developed dark patches that began a month after treatment and faded over about four months; none lost pigment permanently (Sriprachya-anunt 2002). A single, lighter pass of the CO2 laser improved all skin types, and darker skin improved the most despite near-universal temporary darkening (Alster 2003).

Fractional lasers, which treat a grid of tiny columns and leave the skin between them intact, carry less risk. A single fractional CO2 treatment in medium-brown and brown skin caused no dark patches (Tan 2008). In Chinese patients, fractional laser darkening was uncommon, and patches around the mouth appeared when the skin was not cooled during treatment (Chan 2007). Needling caused dark patches less often than the fractional CO2 laser in acne scar treatment (Batool 2026).

Superficial peels are safe in darker skin. About 1 in 25 superficial peels in skin types III to VI caused a problem such as crusting or darkening, and every one resolved; the darkest skin type had the highest risk (Vemula 2018). Reviews advise caution with medium-depth peels and avoiding deep peels in dark skin (Lee 2026, Garelick 2026).

Melasma, a patchy brown pigment of the face that mostly affects women, is treated with creams first. Hydroquinone and triple combination cream work best, while peels and lasers are equal or worse with more side effects (McKesey 2020). An international consensus names sunscreen as essential and supervised triple cream as the standard (Sarkar 2026). A non-ablative laser made melasma worse in a side-by-side trial against cream (Wind 2010).

Where surgeons disagree

  • Lasers for pigment. Fractional CO2 combined with cream held melasma improvement longer than either alone (Trelles 2010). A review of dark spots after inflammation found laser the only treatment that fully cleared spots in some patients, but it worsened spots in others (Mar 2024).
  • Which peel. Pooled trials in darker skin favored glycolic acid over trichloroacetic acid (Dorgham 2020), and a broader review also found glycolic acid the safest and most effective (Sarkar 2024).

What is new

  • Aftercare lowers the risk. A fusidic acid cream after fractional CO2 reduced inflammation and dark patches compared with the usual ointment (Wei 2021).
  • A peel before and after fractional CO2 lowered dark patches in skin types III to V without slowing healing (Hang 2025).
  • Oral tranexamic acid has joined the melasma options, alongside azelaic acid and kojic acid (Sarkar 2026).

What is still unknown

  • Long-term results: melasma trials are small and short, and the condition often returns (McKesey 2020).
  • Results in the darkest skin types: peel studies rarely include them (Garelick 2026).

Key papers

  • Sriprachya-anunt 2002: darkening after laser resurfacing in skin type IV is common and fades.
  • Alster 2003: a single CO2 pass works across all skin types.
  • Chan 2007: risk factors for darkening after fractional laser in Asian skin.
  • Tan 2008: fractional CO2 without darkening in brown skin.
  • Vemula 2018: superficial peels are safe in darker skin.
  • McKesey 2020: creams beat peels and lasers for melasma.
  • Mar 2024: treating dark spots in skin of color.
  • Sarkar 2026: international melasma consensus.

Papers with a plain summary

Newest papers

2026
Efficacy of picosecond Nd:YAG 1064 nm laser in melasma treatment: a real-world retrospective analysis
Lê TT, Lê AV, Tạ HQ, Nguyễn TP, Zevini A, Martinelli D, et al. · Ital J Dermatol Venerol · PMID 42765845
2026
Nonsurgical Facial Rejuvenation: Principles and Techniques in Aesthetic Plastic Surgery
Chennupati V, Kalogeromitros M, Abbott EN, Kwon S, Giannas M, Gergoudis F, et al. · Ann Plast Surg · PMID 42507645
2026
Non-ablative Erbium-YAG 2940-nm Fractional Laser Treats Periorbital Static Wrinkles Safely in Fitzpatrick Skin Types III-IV
Wu X, Yu W, Shen L, Wang X, Shang Y, Peng H, et al. · Aesthetic Plast Surg · PMID 42576062
2026
Combination Approach to Hyperpigmentation: Unveiling Enhanced Aesthetic Results With Microneedling and Pigment-Correcting Peel
Chilukuri S, Diaz I, Gonzalez B, Arvanitidou L · J Clin Aesthet Dermatol · PMID 42482855
2026
Comparing fractional CO₂ laser and needling-based modalities in facial acne scar treatment: a comprehensive systematic review and meta-analysis
Batool A, Abbas MS, Mahin FE, Nawaz J, Jafri SM, Ahmed A, et al. · Lasers Med Sci · Systematic Review · PMID 42334669 · Plain summary
2026
Chemical Peels in Skin of Color: A Scoping Review of Safety, Efficacy, and Practice Patterns
Garelick E, Pohani P, Aswani A, Khan S, Chadha S, Patel T, et al. · Cureus · PMID 42306365
2026
Global consensus on the management of melanin hyperpigmentation disorders
Passeron T, Desai SR, Abdallah M, Al-Niaimi F, Dlova N, Grimes PE, et al. · J Eur Acad Dermatol Venereol · PMID 41362125
2026
Innovations in Refractory Melasma: Mechanism-Based Management and Emerging Therapeutic Strategies
Laguna Rocafort S, Rivera-Díaz J, Bonilla IM, Rabelo-Cartagena J · Cureus · PMID 42170132
2026
Post-inflammatory Hyperpigmentation in Skin of Color: Emerging Therapies and Treatment Algorithms
Persson C, Desai R, Manikkuttiyil C, Multani H, Lirio R, Nueva M, et al. · Cureus · PMID 42153065
2026
2026
Multimodal Approach for Recalcitrant Melasma Using Picosecond Laser and Topical JAK Inhibition: A Case Report
Ashkanani H, AlZaabi M, AlRasheed A, AlDaraji W · J Cosmet Dermatol · PMID 41883035
2026
Delphi consensus on melasma management by international experts and pigmentary disorders society
Sarkar R, Desai SR, Sinha S, Dogra S, Arellano-Mendoza MI, Ailawadi P, et al. · J Eur Acad Dermatol Venereol · PMID 40996222
2026
Noninvasive Cosmetic Treatments for Fitzpatrick IV-VI: A Narrative Review of Safety and Efficacy Guidelines
Lee SS, Burgener MM, Sayyed AA, Catterall L, Koljonen JL, Ruffolo A, et al. · Plast Reconstr Surg Glob Open · PMID 41884758
2026
A Review of Post-Inflammatory Pigmentation Changes: Pathophysiology, Diagnosis and Treatment
Yadav G, Sauder M, Siddha S, Zeinab R, Barakat M, Joseph M · J Cutan Med Surg · PMID 41847987
2026
Microneedle-based Transdermal Patch: A Novel Strategy for Hyperpigmentation Treatment
Yadav A, Gupta N, Alam MS, Thakur S · Recent Adv Drug Deliv Formul · PMID 41832625
2026
Comparative Efficacy of 35 % Glycolic Acid Peel versus 4 % Retinol Peel in Melasma
Rini T, Sarkar R, Verma B, Mendiratta V, Garg T · Dermatol Surg · Randomized Controlled Trial · PMID 40970768
2026
Targeting Melasma: Innovations in Pigment Deposition and Photoaging in Cosmetic Dermatology
Liao T, Luo R, Deng Y, Yang H, Du Y · J Cosmet Dermatol · PMID 41508749
2026
High-Potency Depigmenting Mask Delivered via 1,927-nm Fractional Laser in Refractory Melasma: A Pilot Case Series
Piquero-Casals J, Mir-Bonafé JF, Rozas-Muñoz E, Piquero-Casals V, Morgado-Carrasco D · Case Rep Dermatol · PMID 42499700
2026
Factors Associated With Quality of Life and Treatment Practice Among Melasma Patients in Nepal
Pokhrel S, Sankhi S, Paudel S, Chalise A, Marasine NR · Dermatol Res Pract · PMID 41675240
2025
A Comparative Study of the Efficacy of Chemical Peels and Microneedling in the Treatment of Moderate to Severe Melasma
Batool A, Seger AJ, Akhtar N, Mateen S, Amiruddin MU, Zain M · Cureus · PMID 41523529
2025
Systematic Review and Meta-Analysis of Treatments on Melasma Area Severity Index and Quality of Life
Ribeiro MM, da Silva ACC, Dalagrana H, Galiciolli MEA, Irioda AC, Garlet QI, et al. · Pharmaceutics · PMID 41471132
2025
Emerging topical therapies for melasma: a comparative analysis of efficacy and safety
Suliman RS, Alhuwayshil J, Almuflehi AA, Al Zaghir AK, Alateqi HA, Mohamedin HE, et al. · J Dermatolog Treat · PMID 41307217
2025
Examining an Antioxidant Biostimulating Treatment for Dark, Postinflammatory Hyperpigmentation-Prone Skin
Iglesia S, Reid L, Kononov T, Zahr AS, Robinson C · J Drugs Dermatol · PMID 41037524
2025
Importance of Using Sunscreen After Light or Laser Facial Treatment: A Literature Review
Lee KWA, Chan LKW, Song JK, Lee CH, Kim JH, Yi KH · Life (Basel) · PMID 41010426
2025
Advancements in drug delivery for hyperpigmentation: emerging therapies and future prospects
Deb A, Sb S, B S, Hp SG, Aj R · Cutan Ocul Toxicol · PMID 40591453
2025
Efficacy of Non-Ablative Fractional Laser Combined With Tranexamic Acid in Melasma Treatment: A Randomized Split-Face Trial
Rahimnia A, Hosnian M, Ehsani AH, Nourmohammadpour P, Shadlou Z, Koohian Mohammadabadi M, et al. · J Cosmet Dermatol · Randomized Controlled Trial · PMID 40776769
2025
In Vitro and In Vivo Assessment of an Innovative Peeling System with Azelaic and Tranexamic Acids for Targeted Hyperpigmentation Reduction
Wong R, Sichmann MGO, Sun J, Kim AR, Bianchini RJ, Hermanson KD, et al. · Dermatol Ther (Heidelb) · PMID 40254690
2025
Latin American consensus on the treatment of melasma
Ocampo-Candiani J, Alas-Carbajal R, Bonifaz-Araujo JF, Marín-Castro H, Valenzuela-Ahumada F, Véliz-Barandiarán JL, et al. · Int J Dermatol · PMID 39415312
2025
Keloid Formation and Any Skin Complications in Patients Treated With Isotretinoin and Undergone Any Skin-Related Procedures
Latifaltojar R, Pour Mohammad A, Goodarzi A · J Cosmet Dermatol · PMID 39568321
2025
Review of Applications of Microneedling in Melasma
Chen W, Jian X, Yu B · J Cosmet Dermatol · PMID 39731267
2025
The efficacy of topical treatments for acanthosis nigricans: a systematic review of randomized controlled trials
Alamri A, Alraddadi RA, Alzahrani D, Abualola AH, Maaddawi HA, Alharthy RF, et al. · Front Med (Lausanne) · Systematic Review · PMID 41140645
2024
Safety and Efficacy of Trichloroacetic Acid Peels in the Treatment of Melasma: A Split-face, Randomized, Prospective Trial in Latin American Women
Lorenzo-Ríos D, Arias Berrios G, Cruz Goytía GI, Rocafort SL, Brau Javier CN · J Clin Aesthet Dermatol · PMID 39263263
2024
An Update on New and Existing Treatments for the Management of Melasma
Gan C, Rodrigues M · Am J Clin Dermatol · PMID 38896402
2024
2024
Comparative long-term efficacy of phenol-croton oil chemical peels for persistent melasma at varied Croton tiglium oil concentrations
Maymone MBC, Mirza FN, Steiner D, Ribeiro F, Landau M, Marçon C, et al. · J Am Acad Dermatol · PMID 38574769
2024
Nanosystems with potential application as carriers for skin depigmenting actives
Castro NR, Pinto CDSC, Dos Santos EP, Mansur CRE · Nanotechnology · PMID 38901412
2024
Chemical Peels for Melasma: A Systematic Review
Sarkar R, Lakhani R · Dermatol Surg · Systematic Review · PMID 38530985
2024
Definition of refractory melasma and its treatment: a review
Yao H, Shen S, Gao X, Feng J, Song X, Xiang W · Lasers Med Sci · PMID 38679674
2024
Does Systemic Metformin Have a Role in Treating Melasma?
Ismail SA, Mohamed GA, Mohamedeen KN, Sotohy RSA, Bakr RM · Dermatol Surg · PMID 38416809
2024
Management of Melasma: Laser and Other Therapies-Review Study
Jiryis B, Toledano O, Avitan-Hersh E, Khamaysi Z · J Clin Med · PMID 38592701
2024
Chemical Peels in Treatment of Melasma
Sarkar R, Katoch S · Dermatol Clin · PMID 37977681
2024
Evaluating the Pros and Cons of Fractional CO2 Laser Versus Microneedling in Atrophic Acne Scars in the Skin of Color: A Split Face Study
Agrawal K, Belgaumkar VA, Chavan RB, Pradhan SN · Indian Dermatol Online J · PMID 39640445
2024
Treatment of Post-Inflammatory Hyperpigmentation in Skin of Colour: A Systematic Review
Mar K, Khalid B, Maazi M, Ahmed R, Wang OJE, Khosravi-Hafshejani T · J Cutan Med Surg · Systematic Review · PMID 39075672
2024
Melasma: A Step-by-Step Approach Towards a Multimodal Combination Therapy
Philipp-Dormston WG · Clin Cosmet Investig Dermatol · PMID 38800358
2024
Cosmetic Considerations in Dark-Skinned Patients
Harnchoowong S, Vachiramon V, Jurairattanaporn N · Clin Cosmet Investig Dermatol · PMID 38321987
2023
Topical Treatments for Melasma and Post-inflammatory Hyperpigmentation
Sadick N, Pannu S, Abidi Z, Arruda S · J Drugs Dermatol · PMID 37943277
2023
Skin of color repigmentation after phenol-croton oil chemical peel
Paiva ML, Justo AS, Lemes BM, Capote ACMO, de Castro Maymone MB, Lipinski LC, et al. · J Am Acad Dermatol · PMID 37460064
2023
Unveiling the mystery of Riehl's melanosis: An update from pathogenesis, diagnosis to treatment
Ding Y, Xu Z, Xiang LF, Zhang C · Pigment Cell Melanoma Res · PMID 37401632
2023
Comparative Efficacy of Chemical Peeling Agents in the Treatment of Melasma
Prasad N, Singh M, Malhotra S, Singh N, Tyagi A, Tyagi S · Cureus · PMID 38022044
2023
Cosmetic Treatments with Energy-Based Devices in Skin of Color
Chao JR, Porter JP, Hessler J · Facial Plast Surg · PMID 37557909
2023
Human dermal fibroblast-derived extracellular matrix reduces postinflammatory hyperpigmentation after fractional carbon dioxide laser facial resurfacing in Asians
Choi SM, Kook KS, Park J, Lew BL, Kwon SH · J Cosmet Dermatol · Randomized Controlled Trial · PMID 36943760
2023
Treatment recommendations for acne-associated hyperpigmentation: Results of the Delphi consensus process and a literature review
Taylor S, Elbuluk N, Grimes P, Chien A, Hamzavi I, Alexis A, et al. · J Am Acad Dermatol · PMID 36924935
2023
Efficacy and Safety of Topical Tranexamic Acid Alone or in Combination with Either Fractional Carbon Dioxide Laser or Microneedling for the Treatment of Melasma
Mamdouh Kamal Dawaud S, Hegab DS, Mohamed El Maghraby G, Ahmad El-Ashmawy A · Dermatol Pract Concept · PMID 37557109
2023
New 675 nm Laser Device: The Innovative and Effective Non-Ablative Resurfacing Technique
Piccolo D, Crisman G, Dianzani C, Zalaudek I, Fusco I, Conforti C · Medicina (Kaunas) · PMID 37512057
2023
Treatment of Periorbital Vascularity, Erythema, and Hyperpigmentation
Samaan CB, Cartee TV · Clin Plast Surg · PMID 37169406
2023
Cosmetic Procedures in Patients with Skin of Color: Clinical Pearls and Pitfalls
Desai M, Gill J, Luke J · J Clin Aesthet Dermatol · PMID 36950048
2023
Disorders of hyperpigmentation. Part II. Review of management and treatment options for hyperpigmentation
Ko D, Wang RF, Ozog D, Lim HW, Mohammad TF · J Am Acad Dermatol · PMID 35158001
2023
Trichloroacetic Acid With Microneedling Versus Trichloroacetic Acid Alone for Treating Melasma
Hofny ER, Abdel-Motaleb AA, Hamed SA, Twisy HO · Dermatol Surg · Randomized Controlled Trial · PMID 36533799
2023
Topical and Systemic Therapies in Melasma: A Systematic Review
Sarkar R, Handog EB, Das A, Bansal A, Macarayo MJ, Keshavmurthy V, et al. · Indian Dermatol Online J · PMID 38099013
2023
2022
Comparison of 1064 nm Q-switched Nd:YAG laser and Jessner peeling in melasma treatment
Ertam Sagduyu I, Marakli O, Oraloglu G, Bulut Okut E, Unal I · Dermatol Ther · PMID 36346028
2022
Acne Vulgaris in Skin of Color: A Systematic Review of the Effectiveness and Tolerability of Current Treatments
Pathmarajah P, Peterknecht E, Cheung K, Elyoussfi S, Muralidharan V, Bewley A · J Clin Aesthet Dermatol · PMID 36381183
2022
Evaluation of oral tranexamic acid as a novel treatment for melasma with a high benefit-risk ratio
Simpson J, Peng L, Ting W · J Cosmet Dermatol · PMID 35972476
2022
A split-face comparison of fractional erbium: YAG laser plus Kligman's formula vs. Kligman's formula monotherapy for facial melasma
Nasimi M, Ghiasi M, Lajevardi V, Nasiri F, Shakoei S · Arch Dermatol Res · Randomized Controlled Trial · PMID 34705101
2022
2022
Medical therapies for melasma
Mahajan VK, Patil A, Blicharz L, Kassir M, Konnikov N, Gold MH, et al. · J Cosmet Dermatol · PMID 35854432
2022
Efficacy of cysteamine and methimazole in treating melasma: A comparative narrative review
Niazi S, Gheisari M, Moravvej H, Doroodgar F, Niazi F · J Cosmet Dermatol · PMID 35751542
2022
Factors affecting the outcome of fractional carbon dioxide laser resurfacing of various types of scars in skin of color
Maninder K, Richa R, Dinesh AP, Suman P · J Cosmet Dermatol · PMID 34932873
2022
Treatment of Periorbital Vascularity, Erythema, and Hyperpigmentation
Samaan CB, Cartee TV · Facial Plast Surg Clin North Am · PMID 35934433
2022
Lasers for cutaneous lesions: An update
El Saftawy E, Sarhan R, Hamed A, Elhawary E, Sameh A · Dermatol Ther · PMID 35714173
2022
Management of post-inflammatory hyperpigmentation in skin of color: A short review
Anvery N, Christensen RE, Dirr MA · J Cosmet Dermatol · PMID 35289059
2022
Microneedling as an adjuvant to topical therapies for melasma: A systematic review and meta-analysis
Bailey AJM, Li HO, Tan MG, Cheng W, Dover JS · J Am Acad Dermatol · Meta-Analysis · PMID 33857549
2022
An in vivo model of postinflammatory hyperpigmentation and erythema: clinical, colorimetric and molecular characteristics
Vellaichamy G, Kohli I, Zubair R, Yin C, Braunberger T, Nahhas AF, et al. · Br J Dermatol · PMID 34625951
2022
Combined chemical peels versus trichloroacetic acid (TCA) for treating melasma: a split face study
Atwa MA, Ahmed AH, Nada HA, Refaey SM, Jafferany M, Elsaie ML · J Dermatolog Treat · PMID 32649234
2022
Protocol for development of a core outcome set for clinical trials in melasma
Ibrahim SA, Kang BY, Schlessinger DI, Chiren SG, Tang JC, Kirkham JJ, et al. · BMJ Open · PMID 35121595
2022
Differential diagnosis and management of hyperpigmentation
Yoo J · Clin Exp Dermatol · PMID 33999447
2022
A split face comparative study between intradermal tranexamic acid and Erbium-YAG laser in treatment of melasma
Otb S, Shaarawy E, Sadek A, Abdallah N, Agamia N, Soliman M, et al. · J Dermatolog Treat · PMID 32420770
2022
Effects of Topical Retinoids on Acne and Post-inflammatory Hyperpigmentation in Patients with Skin of Color: A Clinical Review and Implications for Practice
Callender VD, Baldwin H, Cook-Bolden FE, Alexis AF, Stein Gold L, Guenin E · Am J Clin Dermatol · PMID 34751927
2022
Acanthosis Nigricans: An Updated Review
Leung AKC, Lam JM, Barankin B, Leong KF, Hon KL · Curr Pediatr Rev · PMID 36698243
2022
Dermatology: how to manage acne in skin of colour
Chiang C, Ward M, Gooderham M · Drugs Context · PMID 35720053
2022
Dermatology: how to manage facial hyperpigmentation in skin of colour
Moolla S, Miller-Monthrope Y · Drugs Context · PMID 35720052
2021
Tranexamic acid versus fractional carbon dioxide laser in post-acne hyperpigmentation
Tawfic SO, Abdel Hay R, Salim H, Elmasry MF · Dermatol Ther · PMID 34414642
2021
Management of hyperpigmentation: Current treatments and emerging therapies
Nautiyal A, Wairkar S · Pigment Cell Melanoma Res · PMID 33998768
2021
The efficacy of energy-based devices combination therapy for melasma
Iranmanesh B, Khalili M, Mohammadi S, Amiri R, Aflatoonian M · Dermatol Ther · PMID 33665885
2021
Common Dermatologic Procedures and the Associated Complications Unique to Skin of Color
Adotama P, Papac N, Alexis A, Wysong A, Collins L · Dermatol Surg · PMID 34328287
2021
The Use of Tranexamic Acid to Prevent and Treat Post-Inflammatory Hyperpigmentation
Lindgren AL, Austin AH, Welsh KM · J Drugs Dermatol · PMID 33683077
2021
2021
Treatments of Periorbital Hyperpigmentation: A Systematic Review
Michelle L, Pouldar Foulad D, Ekelem C, Saedi N, Mesinkovska NA · Dermatol Surg · Systematic Review · PMID 32740208
2021
A randomized controlled pilot study of a proprietary combination versus sunscreen in melasma maintenance
Chatterjee M, Neema S, Rajput GR · Indian J Dermatol Venereol Leprol · Randomized Controlled Trial · PMID 34379946
2021
Professional-Grade TCA-Lactic Acid Chemical Peel: Elucidating Mode of Action to Treat Photoaging and Hyperpigmentation
Bhardwaj V, Sharma K, Maksimovic S, Fan A, Adams-Woodford A, Mao J · Front Med (Lausanne) · PMID 33681250
2020
Recognizing and Managing Complications in Laser Resurfacing, Chemical Peels, and Dermabrasion
Hamilton MM, Kao R · Facial Plast Surg Clin North Am · PMID 33010868
2020
2020
Reflectance Confocal Microscopy Assessment of the Depigmenting Agents Complex for Melasma Treatment
Agozzino M, Licata G, Giorgio CMR, Babino G, Lupoli A, Sperduti I, et al. · J Clin Aesthet Dermatol · PMID 33133340
2020
Post-Inflammatory Hyperpigmentation: A Review of Treatment Strategies
Shenoy A, Madan R · J Drugs Dermatol · PMID 32845587
2020
Study of oral tranexamic acid, topical tranexamic acid, and modified Kligman's regimen in treatment of melasma
Sahu PJ, Singh AL, Kulkarni S, Madke B, Saoji V, Jawade S · J Cosmet Dermatol · Randomized Controlled Trial · PMID 32346962
2020
Chemical peeling for acne and melasma: current knowledge and innovations
Conforti C, Zalaudek I, Vezzoni R, Retrosi C, Fai A, Fadda S, et al. · G Ital Dermatol Venereol · PMID 31804050
2020
Melasma Treatment: An Evidence-Based Review
McKesey J, Tovar-Garza A, Pandya AG · Am J Clin Dermatol · Systematic Review · PMID 31802394
2020
Ascorbic acid derivative-loaded modified aspasomes: formulation, in vitro, ex vivo and clinical evaluation for melasma treatment
Aboul-Einien MH, Kandil SM, Abdou EM, Diab HM, Zaki MSE · J Liposome Res · PMID 30821553
2020
A Treatment Combination of Peels, Oral Antioxidants, and Topical Therapy for Refractory Melasma: A Report of 4 Cases
Piquero-Casals J, Granger C, Piquero-Casals V, Garre A, Mir-Bonafé JF · Clin Cosmet Investig Dermatol · PMID 32161485
2019
Efficacy and tolerability of using platelet-rich plasma versus chemical peeling in periorbital hyperpigmentation
Ellabban NF, Eyada M, Nada H, Kamel N · J Cosmet Dermatol · Randomized Controlled Trial · PMID 31021041
2019
Comparative Efficacy of a 35% Glycolic Acid Peel Alone or in Combination With a 10% and 20% Trichloroacetic Acid Spot Peel for Melasma: A Randomized Control Trial
Garg S, Thami GP, Bhalla M, Kaur J, Kumar A · Dermatol Surg · Randomized Controlled Trial · PMID 31464703
2019
Modified phenol peels for treatment-refractory hyperpigmentation of lichen planus pigmentosus: A retrospective clinico-dermoscopic analysis
Sonthalia S, Vedamurthy M, Thomas M, Goldust M, Jha AK, Srivastava S, et al. · J Cosmet Dermatol · PMID 30661300
2019
Tranexamic Acid for Melasma: Evaluating the Various Formulations
Wang JV, Jhawar N, Saedi N · J Clin Aesthet Dermatol · PMID 31531176
2019
Comparative study of fractional Erbium: YAG laser vs combined therapy with topical steroid as an adjuvant treatment in melasma
Abdel-Raouf Mohamed H, Ali Nasif G, Saad Abdel-Azim E, Abd El-Fatah Ahmed M · J Cosmet Dermatol · PMID 30146730
2019
Hyperpigmentation Disorders in Hispanic Population in the United States
Rendon MI · J Drugs Dermatol · PMID 30909363
2019
Hyperpigmentation Disorders in Hispanic Population in the United States
Rendon MI · J Drugs Dermatol · PMID 30909362
2019
Treatment of periorbital dark circles: Comparative study of carboxy therapy vs chemical peeling vs mesotherapy
Ahmed NA, Mohammed SS, Fatani MI · J Cosmet Dermatol · Randomized Controlled Trial · PMID 29767467
2019
Clinical & ultrastructural evaluation of the effect of fractional CO2 laser on facial melasma
El-Sinbawy ZG, Abdelnabi NM, Sarhan NE, Elgarhy LH · Ultrastruct Pathol · PMID 31575311
2018
Aesthetic considerations in female skin of color: what you need to know
Henry M, Sadick N · Semin Cutan Med Surg · PMID 30475929
2018
Efficacy of Laser Resurfacing and Facial Plastic Surgery Using Age, Glogau, and Fitzpatrick Rating
Barrera JE, Adame MJ, Lospinoso JA, Beachkofsky TM · Plast Reconstr Surg Glob Open · PMID 30534475
2018
The effects of recombinant human epidermal growth factor containing ointment on wound healing and post inflammatory hyperpigmentation prevention after fractional ablative skin resurfacing: A split-face randomized controlled study
Techapichetvanich T, Wanitphakdeedecha R, Iamphonrat T, Phothong W, Eimpunth S, Jane Hidajat I, et al. · J Cosmet Dermatol · Randomized Controlled Trial · PMID 29956440
2018
Assessing the safety of superficial chemical peels in darker skin: A retrospective study
Vemula S, Maymone MBC, Secemsky EA, Widjajahakim R, Patzelt NM, Saade D, et al. · J Am Acad Dermatol · PMID 29518457
2018
Postinflammatory Hyperpigmentation: Epidemiology, Clinical Presentation, Pathogenesis and Treatment
Kaufman BP, Aman T, Alexis AF · Am J Clin Dermatol · PMID 29222629
2017
Postinflammatory hyperpigmentation: A comprehensive overview: Treatment options and prevention
Chaowattanapanit S, Silpa-Archa N, Kohli I, Lim HW, Hamzavi I · J Am Acad Dermatol · PMID 28917452
2017
2017
Melasma: an Up-to-Date Comprehensive Review
Ogbechie-Godec OA, Elbuluk N · Dermatol Ther (Heidelb) · PMID 28726212
2017
Melasma: systematic review of the systemic treatments
Zhou LL, Baibergenova A · Int J Dermatol · Systematic Review · PMID 28239840
2017
Effectiveness of a Nutraceutical During Non-Ablative 1927 nm Fractional Laser on Patients With Facial Hyperpigmentation and Photoaging
Kaufman-Janette J, Cazzaniga A, Ballin A, Swanson-Garcell R · J Drugs Dermatol · Randomized Controlled Trial · PMID 28628688
2017
Combined Jessner Solution and Trichloroacetic Acid Versus Trichloroacetic Acid Alone in the Treatment of Melasma in Dark-Skinned Patients
Abdel-Meguid AM, Taha EA, Ismail SA · Dermatol Surg · Randomized Controlled Trial · PMID 28178004
2017
Universal Trichloroacetic Acid Peel Technique for Light and Dark Skin
Fanous N, Zari S · JAMA Facial Plast Surg · PMID 28097306
2017
Chemical Peeling: A Useful Tool in the Office
Truchuelo M, Cerdá P, Fernández LF · Actas Dermosifiliogr · PMID 27931952
2017
A review of laser and light therapy in melasma
Trivedi MK, Yang FC, Cho BK · Int J Womens Dermatol · PMID 28492049
2017
Melasma
Lee BW, Schwartz RA, Janniger CK · G Ital Dermatol Venereol · PMID 27589484
2017
Chemical Peels in Melasma: A Review with Consensus Recommendations by Indian Pigmentary Expert Group
Sarkar R, Arsiwala S, Dubey N, Sonthalia S, Das A, Arya L, et al. · Indian J Dermatol · PMID 29263530
2016
[Post-inflammatory hyperpigmentation occuring after cosmetic procedures]
Beylot C, Raimbault-Gerard C · Ann Dermatol Venereol · PMID 29452657
2016
2016
Efficacy of Trichloro-Acetic Acid Peel Alone Versus Combined Topical Magnesium Ascorbyl Phosphate for Epidermal Melasma
Murtaza F, Bangash AR, Khushdil A, Noor SM · J Coll Physicians Surg Pak · Randomized Controlled Trial · PMID 27504543
2016
Nonablative Fractional Laser Resurfacing for Acne Scarring in Patients With Fitzpatrick Skin Phototypes IV-VI
Alexis AF, Coley MK, Nijhawan RI, Luke JD, Shah SK, Argobi YA, et al. · Dermatol Surg · Randomized Controlled Trial · PMID 26945321
2016
Comparative Evaluation of Efficacy and Tolerability of Glycolic Acid, Salicylic Mandelic Acid, and Phytic Acid Combination Peels in Melasma
Sarkar R, Garg V, Bansal S, Sethi S, Gupta C · Dermatol Surg · Randomized Controlled Trial · PMID 26859648
2016
Microneedling in skin of color: A review of uses and efficacy
Cohen BE, Elbuluk N · J Am Acad Dermatol · PMID 26549251
2016
Melasma and Post Inflammatory Hyperpigmentation: Management Update and Expert Opinion
Sofen B, Prado G, Emer J · Skin Therapy Lett · PMID 27224897
2016
Periorbital Hyperpigmentation: A Comprehensive Review
Sarkar R, Ranjan R, Garg S, Garg VK, Sonthalia S, Bansal S · J Clin Aesthet Dermatol · PMID 26962392
2015
Melasma treatment using an erbium:YAG laser: a clinical, immunohistochemical, and ultrastructural study
Attwa E, Khater M, Assaf M, Haleem MA · Int J Dermatol · PMID 25266556
2014
Q-switched Nd: YAG laser versus trichloroacetic acid peeling in the treatment of melasma among Egyptian patients
Moubasher AE, Youssef EM, Abou-Taleb DA · Dermatol Surg · Randomized Controlled Trial · PMID 25068546
2014
Laser skin treatment in non-Caucasian patients
Richter AL, Barrera J, Markus RF, Brissett A · Facial Plast Surg Clin North Am · PMID 25049127
2014
Low-power fractional CO₂ laser versus low-fluence Q-switch 1,064 nm Nd:YAG laser for treatment of melasma: a randomized, controlled, split-face study
Jalaly NY, Valizadeh N, Barikbin B, Yousefi M · Am J Clin Dermatol · Randomized Controlled Trial · PMID 24858737
2013
Glycolic acid peel therapy - a current review
Sharad J · Clin Cosmet Investig Dermatol · PMID 24399880
2013
Salicylic acid for the treatment of melasma: new acquisitions for monitoring the clinical improvement
Fabbrocini G, De Vita V, Marasca C, Palmisano F, Monfrecola G · Skin Res Technol · PMID 23527534
2013
Treatment of melasma with topical agents, peels and lasers: an evidence-based review
Rivas S, Pandya AG · Am J Clin Dermatol · PMID 23881551
2013
Chemical peeling with trichloroacetic acid and lactic acid for infraorbital dark circles
Vavouli C, Katsambas A, Gregoriou S, Teodor A, Salavastru C, Alexandru A, et al. · J Cosmet Dermatol · PMID 23992162
2013
The use of ablative lasers in the treatment of facial melasma
Morais OO, Lemos ÉF, Sousa MC, Gomes CM, Costa IM, Paula CD · An Bras Dermatol · PMID 23739704
2012
Chemical peels for melasma in dark-skinned patients
Sarkar R, Bansal S, Garg VK · J Cutan Aesthet Surg · PMID 23378706
2012
Melasma
Wu IB, Lambert C, Lotti TM, Hercogová J, Sintim-Damoa A, Schwartz RA · G Ital Dermatol Venereol · PMID 23007216
2012
Hyperpigmented burn scar improved with a fractionated 1550 nm non-ablative laser
Bach DQ, Garcia MS, Eisen DB · Dermatol Online J · PMID 22863634
2012
Advances in the treatment of melasma: a review of the recent literature
Ball Arefiev KL, Hantash BM · Dermatol Surg · PMID 22583339
2012
Lasers for treatment of melasma and post-inflammatory hyperpigmentation
Arora P, Sarkar R, Garg VK, Arya L · J Cutan Aesthet Surg · PMID 23060704
2012
Synergistic Combination of an In-office Procedure and Home Regimen for the Treatment of Facial Hyperpigmentation
Cohen JL, Makino E, Sonti S, Mehta R · J Clin Aesthet Dermatol · PMID 22708006
2012
Split-face comparative study of 1550 nm fractional photothermolysis and trichloroacetic acid 15% chemical peeling for facial melasma in Asian skin
Hong SP, Han SS, Choi SJ, Kim MS, Won CH, Lee MW, et al. · J Cosmet Laser Ther · Randomized Controlled Trial · PMID 22372386
2012
Split-face study of melasma patients treated with non-ablative fractionated photothermolysis (1540 nm)
Barysch MJ, Rümmelein B, Kolm I, Karpova MB, Schönewolf N, Bogdan Allemann I, et al. · J Eur Acad Dermatol Venereol · PMID 21521377
2012
Newer and upcoming therapies for melasma
Sarkar R, Chugh S, Garg VK · Indian J Dermatol Venereol Leprol · PMID 22772611
2011
Melasma: a comprehensive update: part II
Sheth VM, Pandya AG · J Am Acad Dermatol · PMID 21920242
2011
Melasma--updated treatments
Situm M, Kolić M, Bolanca Z, Ljubicić I, Misanović B · Coll Antropol · PMID 22220462
2010
Non-ablative 1,550 nm fractional laser therapy versus triple topical therapy for the treatment of melasma: a randomized controlled split-face study
Wind BS, Kroon MW, Meesters AA, Beek JF, van der Veen JP, Nieuweboer-Krobotová L, et al. · Lasers Surg Med · Randomized Controlled Trial · PMID 20806385
2010
The treatment of melasma with topical creams alone, CO2 fractional ablative resurfacing alone, or a combination of the two: a comparative study
Trelles MA, Velez M, Gold MH · J Drugs Dermatol · Randomized Controlled Trial · PMID 20514787
2010
Glycolic acid peels versus amino fruit acid peels in the treatment of melasma
Ilknur T, Biçak MU, Demirtaşoğlu M, Ozkan S · Dermatol Surg · Randomized Controlled Trial · PMID 20187899
2010
Chemical peels for darker skin types
Rullan P, Karam AM · Facial Plast Surg Clin North Am · PMID 20206095
2010
Comparative study of trichloroacetic acid versus glycolic acid chemical peels in the treatment of melasma
Kumari R, Thappa DM · Indian J Dermatol Venereol Leprol · PMID 20657143
2010
Melasma: insights and perspectives
Jadotte YT, Schwartz RA · Acta Dermatovenerol Croat · PMID 20624364
2009
Different therapeutic modalities for treatment of melasma
Azzam OA, Leheta TM, Nagui NA, Shaarawy E, Hay RM, Hilal RF · J Cosmet Dermatol · Randomized Controlled Trial · PMID 19958431
2009
Hyperpigmentation: old problem, new therapies
Que SK, Bergstrom KG · J Drugs Dermatol · PMID 19746682
2009
Melasma: treatment evaluation
Salem A, Gamil H, Ramadan A, Harras M, Amer A · J Cosmet Laser Ther · PMID 19340686
2009
Laser therapy in ethnic populations
Cole PD, Hatef DA, Kaufman Y, Pozner JN · Semin Plast Surg · PMID 20676311
2009
Melasma in Latin America: options for therapy and treatment algorithm
Cestari T, Arellano I, Hexsel D, Ortonne JP, Latin American Pigmentary Disorders Academy · J Eur Acad Dermatol Venereol · PMID 19646135
2009
Management of hyperpigmentation in darker racial ethnic groups
Grimes PE · Semin Cutan Med Surg · PMID 19608057
2008
Topical 10% zinc sulfate solution for treatment of melasma
Sharquie KE, Al-Mashhadani SA, Salman HA · Dermatol Surg · PMID 18616534
2007
The prevalence and risk factors of post-inflammatory hyperpigmentation after fractional resurfacing in Asians
Chan HH, Manstein D, Yu CS, Shek S, Kono T, Wei WI · Lasers Surg Med · PMID 17518354
2007
Efficacy and safety of serial glycolic acid peels and a topical regimen in the treatment of recalcitrant melasma
Erbil H, Sezer E, Taştan B, Arca E, Kurumlu Z · J Dermatol · Randomized Controlled Trial · PMID 17204097
2006
Lactic acid chemical peels as a new therapeutic modality in melasma in comparison to Jessner's solution chemical peels
Sharquie KE, Al-Tikreety MM, Al-Mashhadani SA · Dermatol Surg · PMID 17199649
2006
The treatment of melasma: a review of clinical trials
Gupta AK, Gover MD, Nouri K, Taylor S · J Am Acad Dermatol · PMID 17097400 · Plain summary
2006
Phenol-castor oil: modified peel for dermal melasma
Piamphongsant T · Dermatol Surg · PMID 16706754
2006
Optimal treatments for hyperpigmentation
Ke MS, Soriano T, Lask GP · J Cosmet Laser Ther · PMID 16581679
2005
Lactic acid as a new therapeutic peeling agent in melasma
Sharquie KE, Al-Tikreety MM, Al-Mashhadani SA · Dermatol Surg · PMID 15762205
2005
Treatment of periorbital hyperpigmentation
Gendler EC · Aesthet Surg J · PMID 19338869
2004
Tretinoin peels versus glycolic acid peels in the treatment of Melasma in dark-skinned patients
Khunger N, Sarkar R, Jain RK · Dermatol Surg · PMID 15099320
2004
Efficacy of hydroquinone (2%) versus tretinoin (0.025%) as adjunct topical agents for chemical peeling in patients of melasma
Nanda S, Grover C, Reddy BS · Dermatol Surg · Randomized Controlled Trial · PMID 15008866
2004
The treatment of hypopigmentation after skin resurfacing
Fulton JE, Rahimi AD, Mansoor S, Helton P, Shitabata P · Dermatol Surg · PMID 14692936
2004
Melasma: a review
Victor FC, Gelber J, Rao B · J Cutan Med Surg · PMID 15685388
2004
Utilizing combination therapy to optimize melasma outcomes
Rendon MI · J Drugs Dermatol · PMID 15552597
2004
Optimal management of recalcitrant disorders of hyperpigmentation in dark-skinned patients
Stratigos AJ, Katsambas AD · Am J Clin Dermatol · PMID 15186195
2004
Chemical peeling in ethnic/dark skin
Roberts WE · Dermatol Ther · PMID 15113287
2004
Idiopathic isolated perioral hyperpigmentation and treatment with the erbium:YAG laser
Copcu E, Tugay C, Tugay G · Lasers Med Sci · PMID 15045606
2003
2002
Facial resurfacing in patients with Fitzpatrick skin type IV
Sriprachya-anunt S, Marchell NL, Fitzpatrick RE, Goldman MP, Rostan EF · Lasers Surg Med · PMID 11870786
2001
Chemical peeling--glycolic acid versus trichloroacetic acid in melasma
Kalla G, Garg A, Kachhawa D · Indian J Dermatol Venereol Leprol · PMID 17664715
2000
Disorders of hyperpigmentation
Pandya AG, Guevara IL · Dermatol Clin · PMID 10626115
2000
Management of facial hyperpigmentation
Pérez-Bernal A, Muñoz-Pérez MA, Camacho F · Am J Clin Dermatol · PMID 11702317
1999
The use of chemical peelings in the treatment of different cutaneous hyperpigmentations
Cotellessa C, Peris K, Onorati MT, Fargnoli MC, Chimenti S · Dermatol Surg · PMID 10469091
1999
Erbium:YAG laser resurfacing for refractory melasma
Manaloto RM, Alster T · Dermatol Surg · PMID 10037517
1999
Solar-induced postinflammatory hyperpigmentation after laser hair removal
Hasan AT, Eaglstein W, Pardo RJ · Dermatol Surg · PMID 10037515
1998
1995
Melasma. Etiologic and therapeutic considerations
Grimes PE · Arch Dermatol · PMID 7492140 · Plain summary
1987
Postsclerotherapy hyperpigmentation: a histologic evaluation
Goldman MP, Kaplan RP, Duffy DM · J Dermatol Surg Oncol · PMID 3571692
1976
Dermabrasion of the skin: Prevention and/or treatment of hyperpigmentation
Ferreira JA · Aesthetic Plast Surg · PMID 24173764