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Fat Grafting for Facial Filling and Regeneration

The authors describe how to collect, process and place fat in the face so more of it survives, and state that grafted fat can repair the tissues it is placed into as well as add volume.

Coleman SR, Katzel EB. Clinics in plastic surgery, 2015.

What it means for a patient

  • Fat from the patient's own body can restore fullness lost with age.
  • The authors report that grafted fat can also repair the tissue it is placed in.
  • Past problems with fat grafting included fat that did not survive, fat necrosis and uneven results.
  • According to the authors, technique at each step (collection, processing, placement) affects how much fat is kept.
  • This is a technique article with case reports. It reports no measured results in a group of patients.

Why this paper matters

It presents fat grafting as a treatment that both adds volume and repairs tissue. It sets out collection, processing and placement steps meant to improve graft retention in the face.

Overview

Fat grafting can rejuvenate an aging face by restoring or creating fullness. The authors state that grafted fat does more than add volume: it can transform or repair the tissues into which it is placed. Surgeons had hesitated to use fat grafting because of poor graft take, fat necrosis and inconsistent outcomes. The article describes techniques and practices for collecting, processing and placing fat, with the goals of graft retention and a good facial appearance. It is indexed as a review with case reports. The abstract reports no patient numbers.

Findings

  • Fat grafting can rejuvenate an aging face by restoring or creating fullness.
  • Grafted fat can transform or repair the tissues into which it is placed.
  • Past reasons surgeons hesitated: poor graft take, fat necrosis and inconsistent outcomes.
  • The article covers technique for each step: collection, processing and placement of fat.
  • The stated goals are graft retention and facial aesthetic outcome.
  • The abstract gives no numbers.

Terms

  • Fat grafting: moving fat from one part of the body to another by liposuction and injection.
  • Graft take: the share of grafted fat that survives.
  • Graft retention: how much grafted volume remains over time.
  • Fat necrosis: death of grafted fat cells, which can form firm lumps or oil cysts.
  • Processing: preparing collected fat before injection, for example by centrifuging or filtering.
  • Regeneration: repair or renewal of tissue.
  • Esthetic (aesthetic): relating to appearance.
  • Case report: a description of the treatment and result in one or a few patients.

Newest papers on facial fat grafting, nanofat and microfat

The latest studies on the same subject.

2026
The role of nanofat membranes in inhibiting bacterial growth: An in vitro analysis
Nazari S, Nejatipour Z, Pourani MR, Martins L, Martin-Marfil P, Dezfouli SA, et al. · JPRAS Open · PMID 42730262
2026
Autologous fat-derived products for skin and scar optimization in rhinoplasty and nasal reconstruction: A systematic review
Aljahdali DA, Aljahdali NA, Alharbi RA, AlAbdullah G, Albarrati AM, Almohaimeed NA, et al. · JPRAS Open · PMID 42701521
2026
Autologous Tissue Grafts for Chin Augmentation With or Without Genioplasty: A Systematic Review
Nelke K, Kotela A, Majchrzak Z, Laszczyńska M, Horodniczy T, Wesołek K, et al. · J Clin Med · PMID 42795799

More plain summaries on facial fat grafting, nanofat and microfat

2015
Antiaging treatment of the facial skin by fat graft and adipose-derived stem cells
Charles-de-Sá L, Gontijo-de-Amorim NF, Maeda Takiya C, Borojevic R, Benati D, Bernardi P, et al. · Plast Reconstr Surg · PMID 25811565 · Plain summary
2013
Nanofat grafting: basic research and clinical applications
Tonnard P, Verpaele A, Peeters G, Hamdi M, Cornelissen M, Declercq H · Plast Reconstr Surg · PMID 23783059 · Plain summary
2007
Autologous fat transfer for facial recontouring: is there science behind the art?
Kaufman MR, Miller TA, Huang C, Roostaien J, Wasson KL, Ashley RK, et al. · Plast Reconstr Surg · PMID 17519732 · Plain summary